abstract：:This article was originally published under a CC BY-NC 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly. ...

journal_title：Intensive care medicine

authors： Harris S,Singer M,Sanderson C,Grieve R,Harrison D,Rowan K

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Neurologic and endothelial injury biomarkers are associated with prolonged delirium during critical illness and may reflect injury pathways that lead to poor long-term outcomes. We hypothesized that blood-brain barrier (BBB), neuronal, and endothelial injury biomarkers measured during critical illness are assoc...

journal_title：Intensive care medicine

authors： Hughes CG,Patel MB,Brummel NE,Thompson JL,McNeil JB,Pandharipande PP,Jackson JC,Chandrasekhar R,Ware LB,Ely EW,Girard TD

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Acute kidney injury (AKI) frequently occurs in critically ill patients and often precipitates use of renal replacement therapy (RRT). However, the ideal circumstances for whether and when to start RRT remain unclear. We performed evidence synthesis of the available literature to evaluate the value of biomarkers...

journal_title：Intensive care medicine

authors： Klein SJ,Brandtner AK,Lehner GF,Ulmer H,Bagshaw SM,Wiedermann CJ,Joannidis M

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Polymyxin B-immobilized hemoperfusion (PMX-HP) is an adjuvant therapy for sepsis or septic shock that clears circulating endotoxin. Prior trials have shown that PMX-HP improves surrogate endpoints. We aimed to conduct an evidence synthesis to evaluate the efficacy and safety of PMX-HP in critically ill adult pa...

journal_title：Intensive care medicine

authors： Fujii T,Ganeko R,Kataoka Y,Furukawa TA,Featherstone R,Doi K,Vincent JL,Pasero D,Robert R,Ronco C,Bagshaw SM

更新日期：2018-02-01 00:00:00

abstract：:Owing to an oversight by the authors, Figure 2 in this article was not the version intended for publication. The correct Figure 2, reproduced here, features footnote symbols and Figure 2b includes three studies as described in the main text. ...

journal_title：Intensive care medicine

authors： Fujii T,Ganeko R,Kataoka Y,Furukawa TA,Featherstone R,Doi K,Vincent JL,Pasero D,Robert R,Ronco C,Bagshaw SM

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Limited data exist on the correlation between higher flow rates of high-flow nasal cannula (HFNC) and its physiologic effects in patients with acute hypoxemic respiratory failure (AHRF). We assessed the effects of HFNC delivered at increasing flow rate on inspiratory effort, work of breathing, minute ventilatio...

journal_title：Intensive care medicine

authors： Mauri T,Alban L,Turrini C,Cambiaghi B,Carlesso E,Taccone P,Bottino N,Lissoni A,Spadaro S,Volta CA,Gattinoni L,Pesenti A,Grasselli G

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Critical care ultrasonography has utility for the diagnosis and management of critical illness and is in widespread use by frontline intensivists. As there is a need for research to validate and extend its utility, the Editor of Intensive Care Medicine included critical care ultrasonography as a topic in the IC...

journal_title：Intensive care medicine

authors： Mayo P,Arntfield R,Balik M,Kory P,Mathis G,Schmidt G,Slama M,Volpicelli G,Xirouchaki N,McLean A,Vieillard-Baron A

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:We assessed outcomes in brain-injured patients after implementation of a multi-faceted approach to reduce respiratory complications in intensive care units. METHODS:Prospective nationwide before-after trial. Consecutive adults with acute brain injury requiring mechanical ventilation for ≥24 h in 20 French inte...

journal_title：Intensive care medicine

authors： Asehnoune K,Mrozek S,Perrigault PF,Seguin P,Dahyot-Fizelier C,Lasocki S,Pujol A,Martin M,Chabanne R,Muller L,Hanouz JL,Hammad E,Rozec B,Kerforne T,Ichai C,Cinotti R,Geeraerts T,Elaroussi D,Pelosi P,Jaber S,Dalicha

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To use the World Health Organisation's International Classification of Functioning to measure disability following critical illness using patient-reported outcomes. METHODS:A prospective, multicentre cohort study conducted in five metropolitan intensive care units (ICU). Participants were adults who had been a...

journal_title：Intensive care medicine

authors： Hodgson CL,Udy AA,Bailey M,Barrett J,Bellomo R,Bucknall T,Gabbe BJ,Higgins AM,Iwashyna TJ,Hunt-Smith J,Murray LJ,Myles PS,Ponsford J,Pilcher D,Walker C,Young M,Cooper DJ

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:To examine the association of intravenous iodinated contrast material administration with the subsequent development of post-contrast AKI (PC-AKI), emergent dialysis, and short-term mortality using a propensity score-adjusted analysis of a cohort of intensive care unit (ICU) patients who underwent CT examinatio...

journal_title：Intensive care medicine

authors： McDonald JS,McDonald RJ,Williamson EE,Kallmes DF,Kashani K

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The clinical significance of septic myocardial dysfunction is controversial, a fact that may be explained by the influence of loading conditions. Many indices may be useful to characterize cardiac function during septic shock, but their feasibility and physiological coherence in the clinical setting are unknown...

journal_title：Intensive care medicine

authors： Boissier F,Razazi K,Seemann A,Bedet A,Thille AW,de Prost N,Lim P,Brun-Buisson C,Mekontso Dessap A

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Family members of patients who die in the intensive care unit (ICU) may experience symptoms of stress, anxiety, depression, posttraumatic stress disorder (PTSD), and/or prolonged grief. We evaluated whether grief symptoms were alleviated if the physician and the nurse in charge at the time of death sent the clo...

journal_title：Intensive care medicine

authors： Kentish-Barnes N,Chevret S,Champigneulle B,Thirion M,Souppart V,Gilbert M,Lesieur O,Renault A,Garrouste-Orgeas M,Argaud L,Venot M,Demoule A,Guisset O,Vinatier I,Troché G,Massot J,Jaber S,Bornstain C,Gaday V,Robert R

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To evaluate the association between acute respiratory distress syndrome (ARDS) onset time and prognosis. METHODS:Patients with moderate to severe ARDS (N = 876) were randomly assigned into derivation (N = 520) and validation (N = 356) datasets. Both 28-day and 60-day survival times after ARDS onset were analyz...

journal_title：Intensive care medicine

authors： Zhang R,Wang Z,Tejera P,Frank AJ,Wei Y,Su L,Zhu Z,Guo Y,Chen F,Bajwa EK,Thompson BT,Christiani DC

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To provide evidence-based guidelines for early enteral nutrition (EEN) during critical illness. METHODS:We aimed to compare EEN vs. early parenteral nutrition (PN) and vs. delayed EN. We defined "early" EN as EN started within 48 h independent of type or amount. We listed, a priori, conditions in which EN is o...

journal_title：Intensive care medicine

authors： Reintam Blaser A,Starkopf J,Alhazzani W,Berger MM,Casaer MP,Deane AM,Fruhwald S,Hiesmayr M,Ichai C,Jakob SM,Loudet CI,Malbrain ML,Montejo González JC,Paugam-Burtz C,Poeze M,Preiser JC,Singer P,van Zanten AR,De Waele J

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Sepsis and its progression are known to have a major influence on the coagulation system. Current coagulation tests are of limited use when assessing coagulation in sepsis patients. This study aims to assess the potential for a new functional biomarker of clot microstructure, fractal dimension, to identify chan...

journal_title：Intensive care medicine

authors： Davies GR,Pillai S,Lawrence M,Mills GM,Aubrey R,D'Silva L,Battle C,Williams R,Brown R,Thomas D,Morris K,Evans PA

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Ventricular-arterial (V-A) decoupling decreases myocardial efficiency and is exacerbated by tachycardia that increases static arterial elastance (Ea). We thus investigated the effects of heart rate (HR) reduction on Ea in septic shock patients using the beta-blocker esmolol. We hypothesized that esmolol improve...

journal_title：Intensive care medicine

authors： Morelli A,Singer M,Ranieri VM,D'Egidio A,Mascia L,Orecchioni A,Piscioneri F,Guarracino F,Greco E,Peruzzi M,Biondi-Zoccai G,Frati G,Romano SM

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Acute respiratory distress syndrome (ARDS) is frequently associated with hemodynamic instability which appears as the main factor associated with mortality. Shock is driven by pulmonary hypertension, deleterious effects of mechanical ventilation (MV) on right ventricular (RV) function, and associated-sepsis. ...

journal_title：Intensive care medicine

authors： Vieillard-Baron A,Matthay M,Teboul JL,Bein T,Schultz M,Magder S,Marini JJ

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To develop a liver function-related risk prediction tool to identify acute-on-chronic liver failure patients at greatest risk of in-hospital mortality. METHODS:The LiFe (liver, injury, failure, evaluation) score, was constructed based on the opinions of 157 intensivists within the European Society for Intensiv...

journal_title：Intensive care medicine

authors： Edmark C,McPhail MJW,Bell M,Whitehouse T,Wendon J,Christopher KB

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Sepsis is a major health burden worldwide. Preclinical investigations in animals and retrospective studies in patients have suggested that inhibition of platelets may improve the outcome of sepsis. In this study we investigated whether chronic antiplatelet therapy impacts on the presentation and outcome of seps...

journal_title：Intensive care medicine

authors： Wiewel MA,de Stoppelaar SF,van Vught LA,Frencken JF,Hoogendijk AJ,Klein Klouwenberg PMC,Horn J,Bonten MJ,Zwinderman AH,Cremer OL,Schultz MJ,van der Poll T,MARS Consortium.

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Some patients presenting with acute respiratory failure and meeting the Berlin criteria for acute respiratory distress syndrome (ARDS) lack exposure to common risk factors (CRF). These so-called ARDS mimickers often lack histological diffuse alveolar damage. We aimed to describe such ARDS mimickers lacking CRF ...

journal_title：Intensive care medicine

authors： Gibelin A,Parrot A,Maitre B,Brun-Buisson C,Mekontso Dessap A,Fartoukh M,de Prost N

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Acute heart failure (AHF) causes high burden of mortality, morbidity, and repeated hospitalizations worldwide. This guidance paper describes the tailored treatment approaches of different clinical scenarios of AHF and CS, focusing on the needs of professionals working in intensive care settings. RESULTS:Tissue...

journal_title：Intensive care medicine

authors： Mebazaa A,Tolppanen H,Mueller C,Lassus J,DiSomma S,Baksyte G,Cecconi M,Choi DJ,Cohen Solal A,Christ M,Masip J,Arrigo M,Nouira S,Ojji D,Peacock F,Richards M,Sato N,Sliwa K,Spinar J,Thiele H,Yilmaz MB,Januzzi J

更新日期：2016-02-01 00:00:00

abstract：INTRODUCTION:Approximately 20 years have passed since we reported our results of histologically proven cytomegalovirus (CMV) pneumonia in non-immunocompromised ICU patients. Even if there are more recent reports suggesting that CMV may worsen the outcomes for ICU patients, there is no definite answer to this question: ...

journal_title：Intensive care medicine

authors： Papazian L,Hraiech S,Lehingue S,Roch A,Chiche L,Wiramus S,Forel JM

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:We compared hemodynamic and biological effects of the Cascade system, which uses very high volume hemofiltration (HVHF) (120 mL kg(-1) h(-1)), with those of usual care in patients with septic shock. METHODS:Multicenter, prospective, randomized, open-label trial in three intensive care units (ICU). Adults with ...

journal_title：Intensive care medicine

authors： Quenot JP,Binquet C,Vinsonneau C,Barbar SD,Vinault S,Deckert V,Lemaire S,Hassain AA,Bruyère R,Souweine B,Lagrost L,Adrie C

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Fluid overload is a risk factor for poor outcome in intensive care; thus volume loading should be tailored towards patients who are likely to increase stroke volume. We aimed to evaluate the paediatric predictive ability (stroke volume increase of at least 15 % after fluid bolus) of novel and established volume...

journal_title：Intensive care medicine

authors： Saxena R,Durward A,Steeley S,Murdoch IA,Tibby SM

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To estimate the direct and indirect (contextual) effects of the factorized constituents of selective digestive decontamination and selective oropharyngeal decontamination (SDD/SOD), being topical antibiotic (TA) and protocolized antifungal prophylaxis (PAFP), on ICU-acquired candidemia. METHODS:A broad range o...

journal_title：Intensive care medicine

authors： Hurley JC

更新日期：2015-11-01 00:00:00

abstract：INTRODUCTION:Extracorporeal carbon dioxide removal (ECCO2R) has been proposed for hypercapnic respiratory failure in chronic obstructive pulmonary disease (COPD) exacerbations, to avoid intubation or reduce length of invasive ventilation. Balance of risks, efficacy, and benefits of ECCO2R in patients with COPD is uncle...

journal_title：Intensive care medicine

authors： Sklar MC,Beloncle F,Katsios CM,Brochard L,Friedrich JO

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Evidence of variation in mortality after surgery may indicate preventable postoperative death. We sought to determine if regional differences in outcome were present in surgical patients admitted to critical care in the UK. METHODS:We extracted data on admission characteristics, case mix and outcome of all pat...

journal_title：Intensive care medicine

authors： Gillies MA,Power GS,Harrison DA,Fleming A,Cook B,Walsh TS,Pearse RM,Rowan KM

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Plasma immunoglobulin concentrations are acutely altered in critically ill patients with sepsis. However, the association between immunoglobulin levels on the day of sepsis diagnosis and subsequent mortality is inconsistent. METHODS:Systematic review of studies that report immunoglobulin measurements and morta...

journal_title：Intensive care medicine

authors： Shankar-Hari M,Culshaw N,Post B,Tamayo E,Andaluz-Ojeda D,Bermejo-Martín JF,Dietz S,Werdan K,Beale R,Spencer J,Singer M

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Delirium incidence in intensive care unit (ICU) patients is high and associated with poor outcome. Identification of high-risk patients may facilitate its prevention. PURPOSE:To develop and validate a model based on data available at ICU admission to predict delirium development during a patient's complete I...

journal_title：Intensive care medicine

authors： Wassenaar A,van den Boogaard M,van Achterberg T,Slooter AJ,Kuiper MA,Hoogendoorn ME,Simons KS,Maseda E,Pinto N,Jones C,Luetz A,Schandl A,Verbrugghe W,Aitken LM,van Haren FM,Donders AR,Schoonhoven L,Pickkers P

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Early central venous catheter (CVC) insertion in Ebola virus disease (EVD) is a novel approach and has not previously been described. This report delineates the safety, feasibility and clinical implications of early CVC insertion as the optimum means of vascular access in patients with EVD, in the setting of a ...

journal_title：Intensive care medicine

authors： Rees PS,Lamb LE,Nicholson-Roberts TC,Ardley CN,Bailey MS,Hinsley DE,Fletcher TE,Dickson SJ

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Motion-mode (MM) echography allows precise measurement of diaphragmatic excursion when the ultrasound beam is parallel to the diaphragmatic displacement. However, proper alignment is difficult to obtain in patients after cardiac surgery; thus, measurements might be inaccurate. A new imaging modality named the a...

journal_title：Intensive care medicine

authors： Pasero D,Koeltz A,Placido R,Fontes Lima M,Haun O,Rienzo M,Marrache D,Pirracchio R,Safran D,Cholley B

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Critically ill patients often require CT scans. Adverse events (AE) can occur during intra-hospital transport (IHT). The aim of this prospective study was to determine the diagnostic and therapeutic yield and the safety of CT scans in ICU patients. METHODS:All ICU patients having a CT scan for diagnostic purpo...

journal_title：Intensive care medicine

authors： Aliaga M,Forel JM,De Bourmont S,Jung B,Thomas G,Mahul M,Bisbal M,Nougaret S,Hraiech S,Roch A,Chaumoitre K,Jaber S,Gainnier M,Papazian L

更新日期：2015-03-01 00:00:00

abstract：PURPOSE:Previous observational studies have inconsistently associated early hyperoxia with worse outcomes after cardiac arrest, and have methodological limitations. We tested this association using a high-resolution database controlling for multiple disease-specific markers of severity of illness and care processes. M...

journal_title：Intensive care medicine

authors： Elmer J,Scutella M,Pullalarevu R,Wang B,Vaghasia N,Trzeciak S,Rosario-Rivera BL,Guyette FX,Rittenberger JC,Dezfulian C,Pittsburgh Post-Cardiac Arrest Service (PCAS).

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Caloric insufficiency during the first week of intensive care unit (ICU) stay was reported to be associated with increased infection rates, especially ICU-acquired bloodstream infection (ICU-BSI). However, the predisposition to ICU-BSI by a given pathogen remains not well known. We aimed to determine the impact...

journal_title：Intensive care medicine

authors： Ekpe K,Novara A,Mainardi JL,Fagon JY,Faisy C

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:In patients with severe sepsis, no randomized clinical trial has tested the concept of de-escalation of empirical antimicrobial therapy. This study aimed to compare the de-escalation strategy with the continuation of an appropriate empirical treatment in those patients. METHODS:This was a multicenter non-bl...

journal_title：Intensive care medicine

authors： Leone M,Bechis C,Baumstarck K,Lefrant JY,Albanèse J,Jaber S,Lepape A,Constantin JM,Papazian L,Bruder N,Allaouchiche B,Bézulier K,Antonini F,Textoris J,Martin C,AZUREA Network Investigators.

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:To assess the effects of alveolar recruitment maneuvers (ARMs) on clinical outcomes in patients with acute respiratory distress syndrome (ARDS). METHODS:We conducted a search of the MEDLINE, EMBASE, LILACS, CINAHL, CENTRAL, Scopus, and Web of Science (from inception to July 2014) databases for all (i.e. no lan...

journal_title：Intensive care medicine

authors： Suzumura EA,Figueiró M,Normilio-Silva K,Laranjeira L,Oliveira C,Buehler AM,Bugano D,Passos Amato MB,Ribeiro Carvalho CR,Berwanger O,Cavalcanti AB

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:The concept of weaning-induced cardiac dysfunction emerged 26 years ago with the publication of a clinical study conducted by François Lemaire and collaborators. OBJECTIVES:One objective of this article is to remember the results and the historical context under which our pivotal study was conducted. Anot...

journal_title：Intensive care medicine

authors： Teboul JL

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:This prospective observational study aimed at describing prescription patterns of tigecycline and patient outcomes in 26 French intensive care units (ICU). METHODS:Data of consecutive cases of adult patients treated with tigecycline were collected from the initiation until 7 days after the end of treatment. Re...

journal_title：Intensive care medicine

authors： Montravers P,Dupont H,Bedos JP,Bret P,Tigecycline Group.

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:The efficacy of noninvasive continuous positive airway pressure (CPAP) to improve outcomes in severe hypoxemic acute respiratory failure (hARF) due to pneumonia has not been clearly established. The aim of this study was to compare CPAP vs. oxygen therapy to reduce the risk of meeting criteria for endotracheal ...

journal_title：Intensive care medicine

authors： Brambilla AM,Aliberti S,Prina E,Nicoli F,Del Forno M,Nava S,Ferrari G,Corradi F,Pelosi P,Bignamini A,Tarsia P,Cosentini R

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:Hyperglycaemia is common in the critically ill. The objectives of this study were to determine the prevalence of critical illness-associated hyperglycaemia (CIAH) and recognised and unrecognised diabetes in the critically ill as well as to evaluate the impact of premorbid glycaemia on the association between ac...

journal_title：Intensive care medicine

authors： Plummer MP,Bellomo R,Cousins CE,Annink CE,Sundararajan K,Reddi BA,Raj JP,Chapman MJ,Horowitz M,Deane AM

更新日期：2014-07-01 00:00:00